Amifer IV

Active substance:  Elemental iron

Form: ampoules Solution for injection or concentrate for solution for infusion.

Dosage: 100 mg elemental iron per ampule of 5 ml

packaging: Box 5 ampoules.

Target: patients suffering from iron deficiency with or without anaemia when oral treatment is not possible or is less effective

Amifer IV is indicated for the treatment of iron deficiency in the following indications:

• Where there is a clinical need for a rapid iron supply,
• In patients who cannot tolerate oral iron therapy or who are non-compliant,
• In active inflammatory bowel disease where oral iron preparations are ineffective,
• In chronic kidney disease when oral iron preparations are less effective.

Base:  The total cumulative dose of Amifer IV, equivalent to the total iron deficit (mg), is determined by the haemoglobin level (Hb) and body weight (BW). The dose of Amifer IV must be individually calculated for each patient according to the total iron deficit calculated with the following Ganzoni formula

Total amount of Amifer IV (20 mg of iron per ml) to be administered is equivalent to the total Iron deficit (mg) devides by 20 mg/ml

Simplified method

• Iron deficiency without anemia: 1 IV ampoule each 3 days
• Iron deficiency with anemia

• Initial hemoglobin value: ≥ 10
  • Body weight < 50 kg
    • => 500 mg
  • Body weight 50 à 70 kg
    • => 1000 mg
  • Body weight ≥ 70 kg
    • => 1500 mg
• Initial hemoglobin value: 7 à 10
  • Body weight < 50 kg
    • => 500 mg
  • Body weight 50 à 70 kg
    • => 1500 mg
  • Body weight ≥ 70 kg
    • => 2000 mg
• Initial hemoglobin value: < 7
  • Body weight < 50 kg
  • Body weight 50 à 70 kg
    • => 2000 mg
  • Body weight ≥ 70 kg
    • => 2500 mg

Amifer IV should only be given intravenously.

This may be

– slow intravenous injection (bolus at a rate of 1 ml per minute)

– a drip infusion (diluted only in saline)

– or an injection directly into the venous line of a dialysis machine.

It is recommended not to exceed 200 mg of Amifer IV per day and this 1 to 3 times per week (max 1 day out of 2) ou d’une injection effectuée directement dans la ligne veineuse d’un générateur de dialyse.